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Title: Lmx1a  
Author: World Heritage Encyclopedia
Language: English
Subject: TCF3, NeuroD, EMX homeogene, Early growth response proteins, NOBOX
Publisher: World Heritage Encyclopedia


LIM homeobox transcription factor 1, alpha
Symbols  ; LMX1; LMX1.1
External IDs GeneCards:
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[1][2]


Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[3]


LMX1A has been shown to interact with TCF3[4] and LHX3.[5]


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