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EIF-2 kinase

 

EIF-2 kinase

Regulation of translation initiation via phosphorylation of Ser51 in eIF2's α-subunit.[1]

eIF-2 is a kinase enzyme that phosphorylates eIF-2.[2]

There are four forms in mammals:

These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes in response to various cellular stress response's.

References

  1. ^ Nika J, Rippel S, Hannig EM (January 2001). "Biochemical analysis of the eIF2beta gamma complex reveals a structural function for eIF2alpha in catalyzed nucleotide exchange".  
  2. ^ eIF-2 Kinase at the US National Library of Medicine Medical Subject Headings (MeSH)


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