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Cerebral embolism

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Cerebral embolism

For other uses, see Embolism (disambiguation).
Not to be confused with ebullism or aneurysm.

Embolism
Classification and external resources
ICD-10 9 DiseasesDB MeSH D004617

In medicine, an embolism (plural embolisms; from the Greek ἐμβολισμός "insertion") refers to the lodging of an embolus, which may be a blood clot, a fat globule or a gas bubble in the bloodstream, which can cause a blockage.[1] Such a blockage (vascular occlusion) may affect a part of the body distanced from the actual site of the embolism. This is then not to be confused with a thrombus (a blood clot) which causes a blockage at the site of origin.[2]

Embolization is a procedure that makes specific use of thrombo-emboli to selectively block the blood supply to unwanted processes such as tumours.

Classification

There are different types of embolism, some of which are listed below.

Arterial or venous

Embolism can be classified as to where it enters the circulation either in arteries or in veins. Arterial embolism are those that follow and, if not dissolved on the way, lodge in a more distal part of the systemic circulation. Sometimes, multiple classifications apply; for instance a pulmonary embolism is classified as an arterial embolism as well,[3] in the sense that the clot follows the pulmonary artery carrying deoxygenated blood away from the heart. However, pulmonary embolism is generally classified as a form of venous embolism, because the embolus forms in veins, e.g. deep vein thrombosis.

Arterial

Main article: Arterial embolism

Arterial embolism can cause occlusion in any part of the body. It is a major cause of infarction, (tissue death due to the blockage of blood supply).

An embolus lodging in the brain from either the heart or a carotid artery will most likely be the cause of a stroke due to ischemia.

An arterial embolus might originate in the heart (from a thrombus in the left atrium, following atrial fibrillation or be a septic embolus resulting from endocarditis). Emboli of cardiac origin are frequently encountered in clinical practice. Thrombus formation within the atrium occurs mainly in patients with mitral valve disease, and especially in those with mitral valve stenosis (narrowing), with atrial fibrillation (AF). In the absence of AF, pure mitral regurgitation has a low incidence of thromboembolism.

The risk of emboli forming in idiopathic AF depends on other risk factors such as increasing age, hypertension, diabetes, recent heart failure, or previous stroke. Thrombus formation can also take place within the ventricles, and it occurs in approximately 30% of anterior-wall myocardial infarctions, compared with only 5% of inferior ones. Some other risk factors are poor ejection fraction (<35%), size of infarct, and the presence of AF. In the first three months after infarction, left-ventricle aneurysms have a 10% risk of embolization.

Patients with prosthetic valves also carry a significant increase in risk of thromboembolism. Risk varies, based on the valve type (bioprosthetic or mechanical); the position (mitral or aortic); and the presence of other factors such as AF, left-ventricular dysfunction, and previous emboli.

Emboli often have more-serious consequences when they occur in the so-called "end circulation": areas of the body that have no redundant blood supply, such as the brain and heart.

Venous

Further information: Pulmonary embolism

Assuming a normal circulation, an embolus formed in a systemic vein will always impact in the lungs, after passing through the right side of the heart. This will form a pulmonary embolism that will result in a blockage of the main artery of the lung and can be a complication of deep-vein thrombosis. The most common sites of origin of pulmonary emboli are the femoral veins. The deep veins of the calf are the most common sites of actual thrombi.

Paradoxical (venous to arterial)

In paradoxical embolism, also known as crossed embolism, an embolus from the veins crosses to the arterial blood system. This is generally found only with heart problems such as septal defects (holes in the cardiac septum) between the atria or ventricles. The most common such abnormality is patent foramen ovale, occurring in about 25% of the adult population, but here the defect functions as a valve which is normally closed, because pressure is slightly higher in the left side of the heart. Sometimes, for example if a patient coughs just when an embolus if passing, it might cross to the arterial system.

Direction

The direction of the embolus can be one of two types:

  • Anterograde
  • Retrograde

In anterograde embolism, the movement of emboli is in the direction of blood flow. In retrograde embolism, however, the emboli move in opposition to the blood flow direction; this is usually significant only in blood vessels with low pressure (veins) or with emboli of high weight.

See also

References

External links

  • MR of Fat Embolism Brain Injury from Fat Embolism
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