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Adcy10

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Adcy10

Adenylate cyclase 10 (soluble)
Identifiers
4.6.1.1
RNA expression pattern

Adenylate cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.[1]

Function

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.[2]

Clinical significance

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria.[1]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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