Report of the Nci-Cdc Working Group to Revise the 1985 Nih Radioepidemiological Tables

By Smith, James M.

Book Id: WPLBN0000167371
Format Type: PDF eBook
File Size: 1.2 MB
Reproduction Date: 2005

Title:	Report of the Nci-Cdc Working Group to Revise the 1985 Nih Radioepidemiological Tables
Author:	Smith, James M.
Volume:
Language:	English
Subject:	Health., Medical research, Medical reports
Collections:	Medical Library Collection
Historic Publication Date:
Publisher:	Centers for Disease Control and Prevention


Citation APA MLA Chicago Smith, J. M. (n.d.). Report of the Nci-Cdc Working Group to Revise the 1985 Nih Radioepidemiological Tables. Retrieved from http://www.gutenberg.us/

Excerpt
The Working Group wishes to acknowledge, with gratitude, the service and help of the following group of individuals who provided advice from different viewpoints during the period in which the approach leading to the present report was being worked out. The advisors participated in three meetings at NCI with the Working Group and its consultants, often at no little inconvenience to themselves, and read and commented upon several early drafts. While these individuals cannot be held responsible for the report, it is a better product because of the insights they provided.

Table of Contents
Table of Contents I. Executive Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 II. Background of 1985 Report . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 A. Congressional mandate and its execution . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 B. “Assigned share” . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 C. Methodology used in the 1985 report . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 1. Data sources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. Dose-response models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. Minimal latent period and distribution of risk over time following exposure . . . . . . . . . 9 4. Dependence of excess risk on sex and on age at exposure . . . . . . . . . . . . . . . . . . . . . . . . . . 9 5. Modification of ERR by other exposures and/or by host factors . . . . . . . . . . . . . . . . . . . . . 9 D. Uncertainty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 III. Reasons for Update . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 A. New data, new findings. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 B. New availability of risk data at the level of incidence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 C. Current application of the NIH report different from that originally contemplated. . . . 14 D. New attention to cancer sites less strongly associated with radiation exposure . . . . . . . . 15 E. New analytical approaches and ways of summarizing data . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 F. More attention to uncertainty and presentation of risk. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 G. Interactive computer program an alternative to tabular presentation . . . . . . . . . . . . . 16 H. Use of organ-specific equivalent dose, in sievert (Sv) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 IV. Description of the Approach. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 A. Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 1. Assigned share. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2. Sources of uncertainty. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 B. Sources of data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 C. Choice of cancer types and approach to cancer types . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 D. Estimation of risk coefficients and their statistical uncertainties. . . . . . . . . . . . . . . . . . . . . . 23 1. Solid cancers from the RERF tumor registry report data. . . . . . . . . . . . . . . . . . . . . . . . . . . 23 2. Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3. Thyroid cancer . . . . . . . . . . . . . .