World Health Organization : Technical Report Series, No. 268: Genetics of Vectors and Insecticide Resistance

By A. W. A. Brown, Ph. D.

Book Id: WPLBN0000102479
Format Type: PDF eBook
File Size: 1.9 MB
Reproduction Date: 2005

Title:	World Health Organization : Technical Report Series, No. 268: Genetics of Vectors and Insecticide Resistance
Author:	A. W. A. Brown, Ph. D.
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago A. Brown, Ph. D, A. W. (n.d.). World Health Organization : Technical Report Series, No. 268. Retrieved from http://www.gutenberg.us/

Description
Medical Reference Publication

Excerpt
1. INTRODUCTION The campaigns promoted by WHO against arthropod-borne disease in all parts of the world have during the past 15 years relied heavily upon the use of insecticides, which even at the present time are being employed with remarkable success. However, the development of resistance to some insecticides by populations of certain vector species, as well as the intrinsic undesirability of depending exclusively upon highly persistent chemicals to provide a healthy environment, demand that alternative methods of control be considered. Besides the development of less persistent alternative insecticides, one of the most promising lines for future research and development lies in the field of genetic control. Studies on the nature of insecticide resistance, particularly those carried out since the meeting of the WHO Expert Committee on Insecticides in 1956,l have shown that the phenomenon is due to pre-adaptations which have usually proved to involve single gene alleles, and that the emergence of insecticide-resistant strains is thus a consequence of Darwinian selection. Such studies have contributed to the understanding of the basic physiologcal nature of gene action, and, in addition, have stimulated research on the basic genetics of vector species with particular reference to Musca domestics, Aedes aegypti and Culex pipiens.

Table of Contents
CONTENTS Page 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2 . Insecticide resistance . . . . . . . . . . . . . . . . . . . . . . 6 2.1 Current state of research on genetics of resistance . . . . . . . 6 2.2 Research needs . . . . . . . . . . . . . . . . . . . . . . . 11 3 . Genetics of vectors . . . . . . . . . . .13 3.1 Formal genetics . . .13 3.1.1 Aedes . . . . .14 3.1 . 2 Culex . . . . .14 3.1.3 Anopheles . . .14 3.1 . 4 Musca domesticn15 3.2 Cytogenetics . . . . .16 3.2.1 Crllicidae . . . .16 3 . 2.2 L.insca domesticn16 3.2.3 Other vectors .17 3.3 Physiological and developmental genetics17 3.4 The genetic basis of vector ability . . . 18 3.5 Genetics of behaviour . . .18 3.6 Population and evolutionary genetics .18 3.7 Research needs and priorities . . . .19 4 . Genetic control . . . . . . . . . . . . . . . . .20 4.1 Incompatibility . . . . . . . . . . . . . . . . . . . . . . .21 . . . .4.. 1.1 Cytoplasmic incompatibility . . . . . . . . . . . . . .21 4.1.2 Hybrid sterility . . . . . . . . . . . . . . . . . . . .22 4.2 Deleterious genes . . . . . . . . . . . . . . . . . . . . 23. 4.3 Replacement . . . . . . . . . . . . . . . . . . . . . . . .23 4.4 ArtScial induction of dominant lethality . . . . . . . 23. . . . 4.5 Methods for propagating genes in populations . . . .23 . . . . 4.6 Areas for further research and development . . . . . . . 24. . . 5 . International co-ordination and servicing of research . . . . . . . . 24 5.1 Stimulation and co-ordination of research . . . . . . . . . . . 24 5.2 Servicing of research . . . . . . . . . . . . . . . . . . . . 26 5.2.1 Terminology . . . . . . . . . . . . . . . . . . . . . 26 5.2.2 Dissemination of information . . . . . . . . . . . . . 26 5.2.3 Standard procedures and techniques . . . . . . . . . . 27 5.2.4 Standard strains . . . . . . . . . . . . . . . . . . . 27 5.2.5 Transportation of insects . . . . . . . . . . . . . . . 28 5.2.6 Culture procedures for insects of public health importance . 29 5.3 Training . . . . . . . . . . . . . . . . . . . . . . . . . . 29