How Exposures to Biologics Influence the Induction and Incidence of Asthma

By Zeldin, Darryl C.

Book Id: WPLBN0000041354
Format Type: PDF eBook:
File Size: 0.2 MB
Reproduction Date: 2005

Title:	How Exposures to Biologics Influence the Induction and Incidence of Asthma
Author:	Zeldin, Darryl C.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago C. Zeldi, B. D. (n.d.). How Exposures to Biologics Influence the Induction and Incidence of Asthma. Retrieved from https://www.gutenberg.us/

Description
Government Reference Publication

Excerpt
Excerpt: A number of environmental factors can affect the development and severity of allergy and asthma; however, it can be argued that the most significant inhaled agents that modulate the development of these conditions are biologics. Sensitization to environmental allergens is an important risk factor for the development of asthma. Innate immune responses are often mediated by receptors on mononuclear cells whose primary ligands arise from microorganisms. Many pathogens, especially viruses, target epithelial cells and affect the host immune response to those pathogens. The acquired immune response to an allergen is influenced by the nature of the innate immune system. Products of innate immune responses to microbes promote TH1-acquired responses. In the absence of TH1 responses, TH2 responses can dominate. Central to TH1/TH2 balance is the composition of contaminants that derive from microbes. In this review we examine the biology of the response to allergens, viruses, and bacterial products in the context of the development of allergy and asthma. Key words: asthma, allergy, allergens, endotoxin, respiratory virus, immunoglobulins, tolerance, leukotrienes, neurotrophins. Environ Health Perspect 114:620?626 (2006). doi:10.1289/ehp.8379 [26 January 2006].