Rules for Distinguishing Toxicants That Cause Type I and Type II Narcosis Syndromes

By Veith, Gilman D.

Book Id: WPLBN0000012825
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title:	Rules for Distinguishing Toxicants That Cause Type I and Type II Narcosis Syndromes
Author:	Veith, Gilman D.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago Veith, G. D. (n.d.). Rules for Distinguishing Toxicants That Cause Type I and Type II Narcosis Syndromes. Retrieved from http://www.gutenberg.us/

Description
Government Reference Publication

Excerpt
Excerpt: Narcosis is a reversible state of arrested activity of protoplasmic structures caused by a wide variety of organic chemicals. Veith et al. (1) demonstrated that this nonspecific mode of action was responsible for lethality in the fathead minnow (Pimephales promelas) for many alcohols, ketones, ethers, alkyl halides, and benzene derivatives. The structure-toxicity relationships developed by both Konemann (2) and Veith et al. (1) are very similar and accurately estimate the LC,, of nonreactive, nonpolar chemicals for a wide variety of aquatic organisms (9) using only the n-octanoliwater partition coefficient (log P). The equations presented (1,s) have become known as baseline toxicity models that predict the toxicity of chemicals that act through the nonspecific mechanism of narcosis. In general, more specific mechanisms produce greater toxicity than baseline narcosis. We are attempting to develop structure-toxicity relationships for other mechanisms of lethality and to determine the structural requirements of the chemicals that act through a given mechanism. Since detailed mechanistic studies for all chemicals are not possible, we have clustered chemicals using fish acute toxicity syndromes.