Concentrated Ambient Air Particles Induce Vasoconstriction of Small Pulmonary Arteries in Rats

By Clarke, Robert W.

Book Id: WPLBN0000000508
Format Type: PDF eBook
File Size: 0.8 MB
Reproduction Date: 2005

Title:	Concentrated Ambient Air Particles Induce Vasoconstriction of Small Pulmonary Arteries in Rats
Author:	Clarke, Robert W.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago Clarke, R. W. (n.d.). Concentrated Ambient Air Particles Induce Vasoconstriction of Small Pulmonary Arteries in Rats. Retrieved from http://www.gutenberg.us/

Description
Government Reference Publication

Excerpt
Excerpt: Epidemiologic studies have observed associations between short-term increases in ambient particle concentrations and increases in respiratory and cardiovascular morbidity and mortality rates (1). Prospective cohort studies suggest that people with preexisting cardiopulmonary disease are more susceptible to the effects of urban ambient particles (2). Chronic obstructive pulmonary disease (COPD) is consistently associated with increased relative risk of death in relationship to ambient particulate air pollution (3). Inhalation exposure of rodents to high levels of sulfur dioxide has provided an animal model similar to human COPD (4?7). Recently, this rat model of chronic bronchitis (CB) was used to study the effects of inhaled ambient particles (8,9) using the Harvard Ambient Particle Concentrator (HAPC). This device concentrates ambient outdoor particles in the fine particle range (0.1?2.5 micrometer) for subsequent direct delivery for animal exposure (10,11). These studies demonstrated that concentrated ambient particles (CAPs) induced changes in pulmonary breathing parameters and elicited variable degrees of pulmonary inflammation (8,9).