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Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
The signal transducing chains are often shared between different receptors within this receptor family.[1]
Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors
Immunoglobulin superfamily, Ccr1, Rank, Interleukin 12 receptor, beta 1 subunit, Cytokine receptor
Gene expression, Metabolism, Apoptosis, Growth factor, Cancer
Rank, Interleukin receptor, Protein, Gene, Interleukin 12 receptor, beta 1 subunit
Rank, Interleukin receptor, Protein, Interleukin 12 receptor, beta 1 subunit, Signal transduction
Tyrosine kinase, Cytokine, Gene, Janus kinase 1, Janus kinase 2
Pfam, Rank, Interleukin receptor, InterPro, Gene
Interleukin receptor, Growth hormone receptor, Rank, Interleukin 12 receptor, beta 1 subunit, Insulin-like growth factor 1
Gene, Interferon regulatory factors, Cleft lip and palate, UCSC Genome Browser, Connective tissue