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Title: Rps6ka1  
Author: World Heritage Encyclopedia
Language: English
Subject: Ribosomal s6 kinase
Publisher: World Heritage Encyclopedia


HU-1 redirects here. For the helicopter, see UH-1 Iroquois.

Ribosomal protein S6 kinase, 90kDa, polypeptide 1
Available structures
PDB Ortholog search: RCSB
RNA expression pattern

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.[1]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]


RPS6KA1 has been shown to interact with YWHAB,[3] MAPK1,[4][5][6] IκBα,[7] TOB1[8] and TSC2.[9][10]

See also


Further reading

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