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Pias1

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Pias1

Protein inhibitor of activated STAT, 1
PDB rendering based on 1v66.
Available structures
PDB Ortholog search: RCSB
Identifiers
PIAS1 Gene
RNA expression pattern

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.[1][2][3]

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.[3]

Interactions

PIAS1 has been shown to interact with DNMT3A,[4] STAT1,[5] Small ubiquitin-related modifier 1,[6][7] Sp3 transcription factor,[8] UBE2I[6][7][8] and P53.[7][9]

References

Further reading



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