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Olfactory marker protein

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Title: Olfactory marker protein  
Author: World Heritage Encyclopedia
Language: English
Subject: Synapsin 2, Calgranulin, FMR1, Gap-43 protein, Granin
Publisher: World Heritage Encyclopedia

Olfactory marker protein

olfactory marker protein
Symbol OMP
Entrez 4975
HUGO 8136
OMIM 164340
RefSeq NM_006189
UniProt P47874
Other data
Locus Chr. 11 q14-q21
Olfactory marker protein
solution structure of olfactory marker protein from rat
Symbol Olfactory_mark
Pfam PF06554
InterPro IPR009103
SCOP 1jyt

In molecular biology, olfactory marker protein is a protein involved in signal transduction. It is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a beta sandwich consisting of eight strands in two sheets with a jelly-roll topology.[1] Three highly conserved regions have been identified as possible protein-protein interaction sites in OMP, indicating a possible role for OMP in modulating such interactions, thereby acting as a molecular switch.[2]

External links


  1. ^ Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL (June 2002). "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction". J. Mol. Biol. 319 (3): 823–37.  
  2. ^ Smith PC, Firestein S, Hunt JF (June 2002). "The crystal structure of the olfactory marker protein at 2.3 A resolution". J. Mol. Biol. 319 (3): 807–21.  

This article incorporates text from the public domain Pfam and InterPro IPR009103

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