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Liver X receptor alpha

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Liver X receptor alpha

Nuclear receptor subfamily 1, group H, member 3

PDB rendering based on 1uhl.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; LXR-a; LXRA; RLD-1
External IDs IUPHAR: ChEMBL: GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3).[1][2]

Expression

miRNA hsa-miR-613 autoregulates the human LXRα gene by targeting the endogenous LXRα through its specific miRNA response element (613MRE) within the LXRα 3′-untranslated region. LXRα autoregulates its own suppression via induction of SREBP1c which upregulates miRNA hsa-miR-613.[3]

Function

The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs) and regulate expression of target genes containing LXR response elements.[4][5]Restoration of LXR-alpha expression/function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin.[6]

Interactions

Liver X receptor alpha has been shown to interact with EDF1[7] and Small heterodimer partner.[8]

References

  1. ^ Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP (1996). "The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling". J. Biol. Chem. 271 (16): 9189–92.  
  2. ^ Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ (1995). "LXR, a nuclear receptor that defines a distinct retinoid response pathway". Genes Dev. 9 (9): 1033–45.  
  3. ^ http://mend.endojournals.org/content/25/4/584.abstract
  4. ^ Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, Grooten J, Huygen K (June 2009). "Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice". J. Clin. Invest. 119 (6): 1626–37.  
  5. ^ "Entrez Gene: nuclear receptor subfamily 1". 
  6. ^ Gupta DS, Kaul D, Kanwar AJ, Parsad D (January 2010). "Psoriasis: crucial role of LXR-alpha RNomics.". Genes and Immunity 11.  
  7. ^ Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77.  
  8. ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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