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E2f5

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E2f5

E2F transcription factor 5, p130-binding

PDB rendering based on 1cf7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; E2F-5
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.[1][2] The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.[2]

Interactions

E2F5 has been shown to interact with TFDP1.[1][3]

See also

References

  1. ^ a b Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (April 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc Natl Acad Sci U S A 92 (6): 2403–7.  
  2. ^ a b "Entrez Gene: E2F5 E2F transcription factor 5, p130-binding". 
  3. ^ Hijmans, E M; Voorhoeve P M, Beijersbergen R L, van 't Veer L J, Bernards R (June 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. (UNITED STATES) 15 (6): 3082–9.  

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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