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Transcription factor II B

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Transcription factor II B

General transcription factor IIB

PDB rendering based on 1c9b.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; TF2B; TFIIB
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcription factor IIB (TFIIB) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is encoded by the TFIIB gene.[2][3]

Transcription factor IIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. The protein serves as a bridge between transcription factor IID, which initially recognizes the promoter sequence, and RNA polymerase II.[4] It is involved in the selection of the transcription start site; mutations in TFIIB cause a shift in the transcription start site.[5]

Interactions

Transcription factor IIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID,[6][7] and the RPB1 subunit of RNA polymerase II.[7]

Transcription Factor IIB makes sequence-specific protein-DNA interactions with the B recognition element (BRE), a promoter element flanking the TATA element.[8][9] The role of TFIIB in the vast number of human promoters lacking TATA and BRE elements remains unclear.

Recent study shows that TFIIB links transcription inhibition with the p53-dependent DNA damage response.[10]

See also

References

  1. ^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. p636–637.  
  2. ^ Ha I, Lane WS, Reinberg D (1991). "Cloning of a human  
  3. ^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4.  
  4. ^ "Entrez Gene: GTF2B general transcription factor IIB". 
  5. ^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137.  
  6. ^ Tang H, Sun X, Reinberg D,  
  7. ^ a b Bushnell, David A; Westover KD, Davis RE,  
  8. ^ Lagrange T, Kapanidis AN, Tang H, Reinberg D,  
  9. ^ Littlefield O, Korkhin Y, Sigler PB (1999). "The structural basis for the oriented assembly of a TBP/TFB/promoter complex". Proceedings of the National Academy of Sciences of the USA 96 (24): 13668–13673.  
  10. ^ "TFIIB dephosphorylation links transcription inhibition with the p53-dependent DNA damage response".  

Further reading

External links


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