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Tfiih

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Title: Tfiih  
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Subject: Transcription factor, TATA box, Robert G. Roeder, General transcription factor, TATA-binding protein, XPB, CDK-activating kinase, ERCC2, Transcription factor II A
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Tfiih

general transcription factor IIH, polypeptide 1, 62kDa
Identifiers
Symbol GTF2H1
Alt. symbols BTF2
Entrez HUGO OMIM RefSeq UniProt Locus p15.1-p14
general transcription factor IIH, polypeptide 2, 44kDa
Identifiers
Symbol GTF2H2
Alt. symbols BTF2, TFIIH, BTF2P44, T-BTF2P44
Entrez HUGO OMIM RefSeq UniProt Locus q12.2-13.3
general transcription factor IIH, polypeptide 3, 34kDa
Identifiers
Symbol GTF2H3
Alt. symbols BTF2, TFIIH
Entrez HUGO OMIM RefSeq UniProt Locus q24.31

Transcription factor II Human (TFIIH) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] TFIIH consists of ten subunits, 7 of which (XPD, XPB, p62, p52, p44, p34 and TTDA) form the core complex. The cyclin activating kinase-subcomplex (CDK7, MAT1, and cyclin H) is linked to the core via the XPD protein [2] Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase and ATPase activities and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or if it is supercoiled.

Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle. Next to a vital function in transcription initiation, TFIIH is also involved in nucleotide excision repair.

References

External links

  • Medical Subject Headings (MeSH)

Template:Transcription factors


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