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Title: Tfiia  
Author: World Heritage Encyclopedia
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Subject: Transcription factor, TATA box, Transcription preinitiation complex, Robert G. Roeder, General transcription factor, TATA-binding protein
Publisher: World Heritage Encyclopedia


general transcription factor IIA, 1, 19/37kDa
Symbol GTF2A1
Entrez HUGO OMIM RefSeq UniProt Locus q31
general transcription factor IIA, 2, 12kDa
Symbol GTF2A2
Entrez HUGO OMIM RefSeq UniProt Locus q21.3

Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA.[1] TFIIA is one of several general (basal) transcription factors (GTFs) that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID, a complex composed of the TATA binding protein TBP and TBP-associated factors (TAFs), as well as the factors TFIIB, TFIIE, TFIIF, and TFIIH. Together, these factors are responsible for promoter recognition and the formation of a transcription preinitiation complex (PIC) capable of initiating RNA synthesis from a DNA template.


TFIIA interacts with the TBP subunit of TFIID and aids in the binding of TBP to TATA-box containing promoter DNA.[2] Interaction of TFIIA with TBP facilitates formation of and stabilizes the preinitiation complex. Interaction of TFIIA with TBP also results in the exclusion of negative (repressive) factors that might otherwise bind to TBP and interfere with PIC formation. TFIIA also acts as a coactivator for some transcriptional activators, assisting with their ability to increase, or activate, transcription. The requirement for TFIIA in vitro transcription systems has been variable, and it can be considered either as a GTF and/or a loosely associated TAF-like coactivator. Genetic analysis in yeast has shown that TFIIA is essential for viability.

TFIIA genes

TFIIA is encoded by two separate germ cells.


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