World Library  
Flag as Inappropriate
Email this Article

Lipodermatosclerosis

Article Id: WHEBN0019067576
Reproduction Date:

Title: Lipodermatosclerosis  
Author: World Heritage Encyclopedia
Language: English
Subject: Panniculitis, Peripheral vascular examination, Compression stockings
Collection:
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Lipodermatosclerosis

Lipodermatosclerosis
Classification and external resources
DiseasesDB 30155

Lipodermatosclerosis (also known as "Chronic panniculitis with lipomembranous changes,"[1] "Hypodermitis sclerodermiformis," "Sclerosing panniculitis," and "Stasis panniculitis"[2]:489) is a skin and connective tissue disease. It is a form of lower extremity panniculitis, [3] an inflammation of the layer of fat under the epidermis.[4]

Symptoms

Pain may be the first noticed symptom.[3] People with lipodermatosclerosis have tapering of their legs above the ankles, forming a constricting band resembling an inverted champagne bottle.[3][5] In addition, there may be brownish-red pigmentation and induration.[5]

Causes

The exact cause of lipodermatosclerosis is unknown.[3][6] Venous disease, such as venous incompetence, venous hypertension, and body mass (obesity) may be relevant to the underlying pathogenesis.[3]

Increased blood pressure in the veins (venous hypertension) can cause diffusion of substances, including fibrin, out of capillaries. Fibrotic tissue may predispose the tissue to ulceration. Recurrent ulceration and fat necrosis is associated with lipodermatosclerosis. In advanced lipodermatosclerosis the proximal leg swells from chronic venous obstruction and the lower leg shrinks from chronic ulceration and fat necrosis resulting in the inverted coke bottle appearance of the lower leg.[7]

Lipodermatosclerosis is most commonly diagnosed in middle-aged women.[3]

The origin of lipodermatosclerosis is probably multifactorial, involving tissue hypoxia, leakage of proteins into the interstitium, and leukocyte activation. Studies of patients with lipodermatosclerosis have demonstrated significantly decreased concentrations of cutaneous oxygen associated with decreased capillary density. Capillaries are virtually absent in areas of fibrotic scars, leading to a condition known as atrophie blanche or livedoid vasculopathy. [8]

Treatment

The management of lipodermatosclerosis may include treating venous insufficiency with leg elevation and elastic compression stockings; in some difficult cases, the condition may be improved with the additional use of the fibrinolytic agent, stanozol. Fibronolytic agents use an enzymatic action to help dissolve blood clots.[3][4][5][9]

See also

Notes

External links

Note: This article contains material adapted from the public domain source "Lipodermatosclerosis: Questions and Answers", by the U.S federal government's Genetic and Rare Diseases Information Center


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.