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Chromosome 16 open reading frame 58
C16orf58 Gene

Chromosome 16 open reading frame 58, or C16orf58, also known as FLJ13638 is a protein which in humans is encoded by the C16orf58 gene.[1] The gene itself is 18892 bp long, with mRNA of 2760 bp, and a protein sequence of 468 amino acids. There is a conserved domain of unknown, DUF647. No function has been determined for this gene yet, but it is predicted that it resides in the endoplasmic reticulum in the cytoplasm.[2]

Species distribution

C16orf58 has very interesting conservation in that it has orthologs back through plants and fungi. However, it has not been found in reptiles, birds, or amphibians. The below table shows some, but not all, orthologs which were found using BLAST.[3]

Species Organism Common Name NCBI Accession Sequence Identity E-value Length (AAs) Gene Common Name
Homo sapiens Human NP_073581 100% 0.0 468 C16orf58
Equus Caballus Horse XP_001495510 85% 0.0 468 PREDICTED: similar to UPF0420 protein C16orf58
Canis familiaris Dog XP_547054 85% 0.0 485 similar to CG10338-PA
Mus musculus Mouse Q91W34 81% 0.0 466 cDNA sequence BC017158
Monodelphis domestica Opossum XP_001370394 65% 3e−160 466 PREDICTED: hypothetical protein
Danio rario Zebrafish NP_001103923 53% 4e−112 432 hypothetical protein LOC555936
Drosophila melanogaster Fly NP_609897 40% 3e−69 395 CG10338
Arabidopsis thaliana Thale Cress AAF81284 37% 2e−68 403 Contains similarity to CG10338 gene product from Drosophila melanogaster
Gallus gallus Chicken NP_989823 25% 0.36 1434 protein tyrosine phosphatase, receptor type, U
Xenopus tropicalis Frog AAI22058 31% 3.4 268 Stk19 protein
Saccharomyces cerevisiae Yeast EDZ73379 25% 0.21 1578 YDL140Cp-like protein
Caenorhabditis elegans Nematode NP_502300 19% 3.0 414 hypothetical protein M18.6

Protein Interactions

Though the function is still unknown, C16orf58 has been shown to interact with three different proteins:

  • BSCL2[6] BSCL2 is the Bernardinelli-Seip congenital lipodystrophy 2, or seipin.[7] It located in the endoplasmic reticulum and is thought to be important in the lipid droplet morphology.
  • TSC22D4[6] The third interacting protein is TSC22D4, TSC22 domain family member 4, and functions as a leucine zipper translational regulation.[8]


Although there are several sites that will give predictions on protein structure, C16orf58 does not have a known structure yet. That being said there is at least one transmembrane domain, if not more. Within the protein structure there are several extended areas with uncharged amino acids, these could be possible transmembrane domains, or hydrophobic cores.[2] The below shows the charge of each of the amino acids in the protein sequence, + for positive, - for negative and 0 for uncharged. Note the large segments of uncharged amino acids appear bolded. These stretches of uncharged amino acids are conserved back through distant orthologs.

      1  00—000-00 000-00000- 0+00+000-0 0000-0000+ 00000+0000 +0-0+-00-0 
     61  0000000000 0000000000 000-0000-0 000000-000 0000000000 0000000000 
    121  0000+00000 0000000+-0 00000+0000 00+00+0-00 0+00+000-0 00-00000-0 
    181  0000000000 000000000+ 0000000000 +00000000+ +0000-000+ -000-00000 
    241  0000000000 0000000000 0000000000 000000+00+ 0000-000-0 +0+000+000 
    301  0+0-00-000 00+0-00000 0000000000 0000+00000 0-00000-00 0-000000-0 
    361  0000000000 0+000+000+ 0000000000 000-00000- 0—0+0+0+0 00++-00000 
    421  +-00-00-00 00+00+000- 000+0-+000 -00-0+0000 000-++00


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