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Fomivirsen

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Title: Fomivirsen  
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Fomivirsen

Fomivirsen
Clinical data
AHFS/Drugs.com
Pregnancy
category
Routes of
administration
Intravitreal injection
Identifiers
CAS Registry Number  YesY
ATC code S01
KEGG  YesY
ChEMBL  N
Chemical data
Formula C204H263N63O114P20S20
Molecular mass 6682.4 g/mol
 N   

Fomivirsen (brand name Vitravene) is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. It was licensed by the FDA for CMV in Aug 1998.

It is a synthetic 21 member oligonucleotide with phosphorothioate linkages (which are resistant to degradation by nucleases) and has the sequence:

  • 5'-GCG TTT GCT CTT CTT CTT GCG-3'

Contents

  • Mechanism 1
  • Administration 2
  • See also 3
  • References 4
  • Further reading 5
  • External links 6

Mechanism

It is an oligonucleotide[1] that blocks translation of viral mRNA by binding to the complementary sequence of the mRNA transcribed from the template segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.[2]

Administration

It is available as an intraocular injection in a concentration of 6.6 mg/mL.[3]

See also

References

  1. ^
  2. ^
  3. ^

Further reading

External links


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