Normal Histology of the Nasal Cavity and Application of Special Techniques

By Uraih, Linda C.

Book Id: WPLBN0000010487
Format Type: PDF eBook:
File Size: 2.23 MB
Reproduction Date: 2005

Title:	Normal Histology of the Nasal Cavity and Application of Special Techniques
Author:	Uraih, Linda C.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago C. Urai, B. L. (n.d.). Normal Histology of the Nasal Cavity and Application of Special Techniques. Retrieved from https://www.gutenberg.us/

Description
Government Reference Publication

Excerpt
Excerpt: Many of earlier rodent toxicity and carcinogenicity studies did not routinely examine the nasal cavity. More recently, studies performed by the National Toxicology Program or other institutes in which animals were exposed either parenterally (1) or via inhalation (2) highlighted the importance of the nasal cavity as apotential target orean. However. the inteeritv of some of these stukes 6 sch allengedwhen the nasal cavity, although suspected, could not be verified as the primary site of tumor development for metastatic lesions found in the brains of affected animals, due simply to failure to col- lect the nasal tissues. In addition, some epithelial typesrein the nasal cavity have been shown to exhibit suscep-tibility to certain gases or chemicals (3-5) that could accouniior the iirr specificity oft he k!siuns iduceTdh.e sr ohservationa indicate the need for iistuogri(c!v iew of nasal tissues for toxicity and carcinogenicity studies and consistency in sectioning and properly documenting the nature and distribution of nasal lesions. The anatomical complexity of the nose, however, may present a challenge to workers that are not routinely engaged in reviewing thisorgan.