Immunological Studies on Mice Exposed Subacutely to Methyl Isocyanate

By Tucker, Anne N.

Book Id: WPLBN0000008368
Format Type: PDF eBook:
File Size: 0.2 MB
Reproduction Date: 2005

Title:	Immunological Studies on Mice Exposed Subacutely to Methyl Isocyanate
Author:	Tucker, Anne N.
Volume:
Language:	English
Subject:	Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections:	Government Library Collection, Disarmament Documents
Historic Publication Date:
Publisher:	United Nations- Office for Disarmament Affairs (Unoda)


Citation APA MLA Chicago N. Tucke, B. A. (n.d.). Immunological Studies on Mice Exposed Subacutely to Methyl Isocyanate. Retrieved from https://www.gutenberg.us/

Description
Government Reference Publication

Excerpt
Excerpt: Although the lung is recognized as the primary target organ of methyl isocyanate (MIC), the toxicological evaluation recently undertaken by the National Toxicology Program included genetic toxicity, reproductive toxicity, and immunotoxicity studies. Toxicity in these organ systems could result from secondary, if not primary, effects of MIC. In order to maximize any potential of this highly reactive chemical to reach remote tissues, the specialized studies were conducted on animals exposed subacutely. The immunotoxicity studies reported here were composed of selected assays for immune function and host resistance following exposure of female B6C3F1 mice to 0, 1, or 3 ppm MIC for 6 hr periods on 4 consecutive days. With this exposure regimen, 3 ppm represents approximately one-half the LCE0. NO deaths occurred at 3 ppm, although pulmonary pathology was present. General toxicity was indicated by the lethargic appearance of the mice following exposure, a significantly decreased body weight on the day following the last exposure, and significant decreases in spleen and thymus weights 7 days after the last exposure (1). All but certain lung changes were reversible within 28 days.