World Library  
Flag as Inappropriate
Email this Article

Tead4

Article Id: WHEBN0015075281
Reproduction Date:

Title: Tead4  
Author: World Heritage Encyclopedia
Language: English
Subject: Transcription factor, Hippo signaling pathway, NeuroD, EMX homeogene, Engrailed (gene)
Collection: Transcription Factors
Publisher: World Heritage Encyclopedia
Publication
Date:
 

Tead4

TEA domain family member 4
PDB rendering based on 2hzd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols  ; EFTR-2; RTEF1; TCF13L1; TEF-3; TEF3; TEFR-1; hRTEF-1B
External IDs GeneCards:
RNA expression pattern
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
PubMed search

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.[1][2][3] This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[4] It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.[3]

References

  1. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9.  
  2. ^ Stewart AF, Richard CW 3rd, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN (Feb 1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics 37 (1): 68–76.  
  3. ^ a b "Entrez Gene: TEAD4 TEA domain family member 4". 
  4. ^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–12.  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4.  
  • Hsu DK, Guo Y, Alberts GF, et al. (1996). "Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation". J. Biol. Chem. 271 (23): 13786–95.  
  • Jacquemin P, Hwang JJ, Martial JA, et al. (1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain". J. Biol. Chem. 271 (36): 21775–85.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56.  
  • Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation". Development 126 (21): 4807–16.  
  • Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.  
  • Chen HH, Baty CJ, Maeda T, et al. (2005). "Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation". Circulation 110 (19): 2980–7.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8.  
  • Appukuttan B, McFarland TJ, Davies MH, et al. (2007). "Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina". Invest. Ophthalmol. Vis. Sci. 48 (8): 3775–82.  

External links


This article was sourced from Creative Commons Attribution-ShareAlike License; additional terms may apply. World Heritage Encyclopedia content is assembled from numerous content providers, Open Access Publishing, and in compliance with The Fair Access to Science and Technology Research Act (FASTR), Wikimedia Foundation, Inc., Public Library of Science, The Encyclopedia of Life, Open Book Publishers (OBP), PubMed, U.S. National Library of Medicine, National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health (NIH), U.S. Department of Health & Human Services, and USA.gov, which sources content from all federal, state, local, tribal, and territorial government publication portals (.gov, .mil, .edu). Funding for USA.gov and content contributors is made possible from the U.S. Congress, E-Government Act of 2002.
 
Crowd sourced content that is contributed to World Heritage Encyclopedia is peer reviewed and edited by our editorial staff to ensure quality scholarly research articles.
 
By using this site, you agree to the Terms of Use and Privacy Policy. World Heritage Encyclopedia™ is a registered trademark of the World Public Library Association, a non-profit organization.
 


Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.